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Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: a retrospective study.

Journal article
Authors Göran Zellin
Lars Rasmusson
Jan Pålsson
Karl-Erik Kahnberg
Published in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Volume 62
Issue 6
Pages 662-6
ISSN 0278-2391
Publication year 2004
Published at Institute of Odontology, Department of Oral and Maxillofacial Surgery
Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care
Pages 662-6
Language en
Keywords Adolescent, Adult, Anesthesia, Dental, methods, Blood Loss, Surgical, prevention & control, Combined Modality Therapy, methods, Deamino Arginine Vasopressin, therapeutic use, Drug Therapy, Combination, Female, Hemostatics, therapeutic use, Humans, Hypotension, Controlled, Male, Maxilla, surgery, Middle Aged, Oral Hemorrhage, prevention & control, Osteotomy, Le Fort, methods, Retrospective Studies, Tranexamic Acid, therapeutic use
Subject categories Dentistry


PURPOSE: Correction of dentofacial deformities by orthognathic surgery may cause significant bleeding and therefore hypotensive anesthesia is often used to reduce the blood loss. The main objective of the present clinical study was to determine whether the addition of hemorrhage depressors to other medication during orthognathic surgery would further reduce the blood loss. PATIENTS AND METHODS: Thirty patients, consecutively operated on with standardized Le Fort I osteotomies in 1998 (n = 15, control group) and 1999 (n = 15, treatment group), were included in the study. Both groups received hypotension anesthesia during surgery and the treatment group received additional hemorrhage depressors; tranexamic acid and desmopressin. RESULTS: The mean blood loss was 740 +/- 410 mL (11.3 mL/kg) in the control group and 400 +/- 210 mL (5.7 mL/kg) in the treatment group. The results showed a statistically significant reduction of blood loss in the treatment group (P <.01). CONCLUSIONS: This study shows that blood loss during orthognathic surgery under hypotensive anesthesia can be significantly reduced when a combination of tranexamic acid and desmopressin is added.

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