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Differential expression of intestinal membrane transporters in cholera patients.

Journal article
Authors Carl-Fredrik Flach
Firdausi Qadri
Taufiqur Rahman Bhuiyan
N. H. Alam
Eva Jennische
Jan Holmgren
Ivar Lönnroth
Published in FEBS letters
Volume 581
Issue 17
Pages 3183-8
ISSN 0014-5793
Publication year 2007
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Institute of Biomedicine, Department of Infectious Medicine
Pages 3183-8
Language en
Links dx.doi.org/10.1016/j.febslet.2007.0...
Subject categories Medical and Health Sciences

Abstract

Vibrio cholerae causes the cholera disease through secretion of cholera toxin (CT), resulting in severe diarrhoea by modulation of membrane transporters in the intestinal epithelium. Genes encoding membrane-spanning transporters identified as being differentially expressed during cholera disease in a microarray screening were studied by real-time PCR, immunohistochemistry and in a CaCo-2 cell model. Two amino acid transporters, SLC7A11 and SLC6A14, were upregulated in acute cholera patients compared to convalescence. Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. The majority of these changes appear to be attempts of the host to counteract the secretory response. Our results also support the concept that epithelial cells are involved in 5-HT signalling during acute cholera.

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