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Major determinants of height development in Turner syndrome (TS) patients treated with GH: analysis of 987 patients from KIGS

Journal article
Authors M. B. Ranke
A. Lindberg
A. Ferrandez Longas
F. Darendeliler
Kerstin Albertsson-Wikland
D. Dunger
W. S. Cutfield
M. Tauber
P. Wilton
H. A. Wollmann
E. O. Reiter
Published in Pediatr Res
Volume 61
Issue 1
Pages 105-10
ISSN 0031-3998 (Print)
Publication year 2007
Published at Institute of Clinical Sciences
Pages 105-10
Language en
Keywords Adolescent, Body Height/*drug effects, Child, Female, Human Growth Hormone/*therapeutic use, Humans, Turner Syndrome/*drug therapy
Subject categories Medical and Health Sciences


Little is known about factors determining height outcome during GH treatment in Turner syndrome (TS). We investigated 987 TS children within the Kabi International Growth Study (KIGS) who had reached near adult height (NAH) after >4 y GH treatment (including >1 y before puberty). Through multiple regression analysis we developed a model for NAH and total gain. Our results were as follows (median): 1) At start, age 9.7 yrs, height (HT) 118.0 cm (0.0 TS SDS), projected adult height 146.1 cm, GH dose 0.27 mg/kg wk; 2) NAH HT 151.0 cm (1.5 TS SDS); 3) Prepubertal gain 21.2 cm (1.6 TS SDS); 4) Pubertal gain 9.4 cm (0.0 TS SDS). NAH correlated (r = 0.67) with (ranked) HT at GH start (+), 1 year responsiveness to GH (+), MPH (+), age at puberty onset (+), age at GH start (-), and dose (+). The same factors explained (R = 0.90) the total HT gain. However, HT at GH start correlated negatively. Karyotype had no influence on outcome. Evidently, height at GH start (the taller, the better), age at GH start (the younger, the better), the responsiveness to GH (the higher, the better) and age at puberty (the later, the better) determine NAH.

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