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Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic fibrosis

Journal article
Authors M. C. Boguszewski
T. O. Kamoi
R. Bento Radominski
C. L. Boguszewski
Sten Rosberg
N. A. Filho
R. Sandrini Neto
Kerstin Albertsson-Wikland
Published in Horm Res
Volume 67
Issue 5
Pages 250-6
ISSN 0301-0163 (Print)
Publication year 2007
Published at Institute of Clinical Sciences
Pages 250-6
Language en
Keywords Adipose Tissue/anatomy & histology, Adolescent, Biological Markers/blood, *Body Composition, Child, Child Development, Child, Preschool, Cross-Sectional Studies, Cystic Fibrosis/*blood, Female, Humans, Inflammation/blood, Insulin-Like Growth Factor I/*analysis, Leptin/*blood, Male
Subject categories Medical and Health Sciences


BACKGROUND/AIMS: Children with cystic fibrosis (CF) are of increased risk of reduced fat body mass (FBM) and lean body mass (LBM). Serum concentrations of insulin-like growth factor-1 (IGF-1)and leptin could be markers of LBM and/or FBM depletion. To evaluate the relationships between disease activity, body composition, IGF-1 and leptin concentrations in CF children. METHODS: A cross-sectional study with 26 CF children aged 5.0-15.5 years and 33 healthy controls, mean age 9.4 years. Body composition was evaluated by dual-energy X-ray absorptiometry. Fasting blood samples were analyzed for leptin, IGF-1 and IGFBP-3. RESULTS: FBM standard deviation score (SDS; CF boys -0.02 +/- 0.88 vs. 0.78 +/- 0.65, p < 0.01; CF girls -0.37 +/- 1.15 vs. 0.70 +/- 0.97, p < 0.05), leptin concentration (CF boys 2.07 +/- 0.79 vs. 3.07 +/- 1.28 ng/ml, p < 0.05; CF girls 2.71 +/- 0.86 vs. 5.00 +/- 2.95 ng/ml, p < 0.05) and IGF-1SDS (CF boys -1.43 +/- 1.50 vs. -0.32 +/- 0.88, p < 0.05; CF girls -0.66 +/- 1.66 vs. 0.64 +/- 0.57, p < 0.01) were lower in CF children compared to controls. Shwachman score was the strongest predictor of lean body mass (R = 0.63). Leptin levels explain 60% of the variability in FBM. CONCLUSION: Serum concentrations of IGF-1 and leptin are decreased in children with CF and are associated with clinical conditions and body composition.

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