To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

The universal influenza v… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.

Journal article
Authors Marina De Filette
Anna Ramne
Ashley Birkett
Nils Y Lycke
Björn Löwenadler
Willy Min Jou
Xavier Saelens
Walter Fiers
Published in Vaccine
Volume 24
Issue 5
Pages 544-51
ISSN 0264-410X
Publication year 2006
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 544-51
Language en
Keywords Adjuvants, Immunologic, pharmacology, Administration, Intranasal, Animals, Antibodies, Viral, analysis, biosynthesis, Cholera Toxin, pharmacology, Female, Humans, Immunization, Influenza Vaccines, administration & dosage, adverse effects, immunology, Influenza, Human, immunology, prevention & control, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Recombinant Fusion Proteins, pharmacology
Subject categories Medical and Health Sciences


Mucosal vaccination requires effective and safe adjuvants. We have evaluated the non-toxic adjuvant CTA1-DD for mucosal vaccination against influenza. CTA1-DD contains the enzymatically active CTA1 subunit of cholera toxin (CT) genetically fused to a gene encoding a dimer of the D-fragment from Staphylococcus aureus protein A. CTA1-DD only binds to Ig-receptor carrying cells of the immune system. Nasal administration of the universal influenza vaccine M2e-HBc in combination with CTA1-DD completely protected mice from a potentially lethal infection and significantly reduced morbidity. Sera of mice immunized with M2e-HBc + CTA1-DD revealed IgG subclass profiles consistent with an enhanced Th1-type immunity. When the vaccine was administered intraperitoneally, the adjuvant improved the M2e antibody titer in circulation, but did not significantly reduce the morbidity.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?