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The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.

Journal article
Authors Marina De Filette
Anna Ramne
Ashley Birkett
Nils Y Lycke
Björn Löwenadler
Willy Min Jou
Xavier Saelens
Walter Fiers
Published in Vaccine
Volume 24
Issue 5
Pages 544-51
ISSN 0264-410X
Publication year 2006
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 544-51
Language en
Links dx.doi.org/10.1016/j.vaccine.2005.0...
Keywords Adjuvants, Immunologic, pharmacology, Administration, Intranasal, Animals, Antibodies, Viral, analysis, biosynthesis, Cholera Toxin, pharmacology, Female, Humans, Immunization, Influenza Vaccines, administration & dosage, adverse effects, immunology, Influenza, Human, immunology, prevention & control, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Recombinant Fusion Proteins, pharmacology
Subject categories Medical and Health Sciences

Abstract

Mucosal vaccination requires effective and safe adjuvants. We have evaluated the non-toxic adjuvant CTA1-DD for mucosal vaccination against influenza. CTA1-DD contains the enzymatically active CTA1 subunit of cholera toxin (CT) genetically fused to a gene encoding a dimer of the D-fragment from Staphylococcus aureus protein A. CTA1-DD only binds to Ig-receptor carrying cells of the immune system. Nasal administration of the universal influenza vaccine M2e-HBc in combination with CTA1-DD completely protected mice from a potentially lethal infection and significantly reduced morbidity. Sera of mice immunized with M2e-HBc + CTA1-DD revealed IgG subclass profiles consistent with an enhanced Th1-type immunity. When the vaccine was administered intraperitoneally, the adjuvant improved the M2e antibody titer in circulation, but did not significantly reduce the morbidity.

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