To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Membrane progesterone rec… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube.

Journal article
Authors Magdalena Nutu
Birgitta Weijdegård
Peter Thomas
Christina Bergh
Ann Thurin-Kjellberg
Yefei Pang
Håkan Billig
D. G. Joakim Larsson
Published in Molecular reproduction and development
Volume 74
Issue 7
Pages 843-50
ISSN 1040-452X
Publication year 2007
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Clinical Sciences
Pages 843-50
Language en
Links dx.doi.org/10.1002/mrd.20685
Keywords Animals, Cell Line, Cilia, metabolism, Fallopian Tubes, cytology, metabolism, Female, Humans, Liver, cytology, metabolism, Mice, Mice, Inbred C57BL, Progesterone, metabolism, Protein Isoforms, genetics, metabolism, Receptors, Progesterone, genetics, metabolism, Tissue Distribution
Subject categories Physiology

Abstract

Non-genomic, rapid actions of steroids have long been known, suggesting the possible presence of non-classical steroid receptors. A membrane receptor for progestins (mPR) was recently described in the spotted seatrout, and transcripts of three related receptors (alpha, beta, and gamma) were subsequently identified in other species including human and mouse. To begin exploring the roles of mPRgamma in mammals, we have generated an antibody against this receptor. The specificity of the antibody was demonstrated by both overexpression and RNA interference experiments. Using the antibody, we show that mPRgamma is expressed in female mouse reproductive tissues such as ovary and fallopian tube, and also in the lung and liver of both sexes. Immunohistochemical studies revealed that mPRgamma is associated with the apical membrane of ciliated cells facing the lumen of the fallopian tube. The presence of mPRgamma in ciliated cells of the fallopian tube was also demonstrated in human samples. Rapid effects of progesterone on ciliary beat frequency in the fallopian tube have recently been reported. Together, this suggests a common role for mPRgamma in the regulation of ciliary activity in the fallopian tube and thus gamete transport in mammals. The presence of mPRgamma in lung and liver of mice suggests that the receptor mediates the actions of progesterone outside the reproductive tract as well.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?