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Soft tissue healing at titanium implants coated with type I collagen. An experimental study in dogs.

Journal article
Authors Maria Welander
Ingemar Abrahamsson
Elena Linder
Birgitta Liljenberg
Tord Berglundh
Published in Journal of clinical periodontology
Volume 34
Issue 5
Pages 452-8
ISSN 0303-6979
Publication year 2007
Published at Institute of Odontology
Pages 452-8
Language en
Keywords Animals, Coated Materials, Biocompatible, Collagen Type I, Connective Tissue, anatomy & histology, physiology, ultrastructure, Dental Implantation, Endosseous, Dental Implants, Dogs, Epithelium, anatomy & histology, physiology, ultrastructure, Gingiva, anatomy & histology, physiology, ultrastructure, Implants, Experimental, Mouth Mucosa, anatomy & histology, physiology, ultrastructure, Swine, Titanium, Wound Healing, physiology
Subject categories Dentistry, Biomaterials


OBJECTIVE: To analyse the soft tissue healing at titanium implants coated with type 1 collagen. MATERIAL AND METHODS: Six dogs were used. The mandibular pre-molars and the three anterior maxillary pre-molars were extracted. Three months later mucoperiosteal flaps were raised and two test and two control implants were installed (3i TG Osseotite 3.75 x 10 and 2.8 mm transmucosal collar). The test implants were coated with a purified porcine type I collagen. Cover screws were placed and flaps were sutured. The sutures were removed 2 weeks later and a plaque-control programme was initiated. Another 2 weeks later, the procedure was repeated in the contra-lateral mandibular region. Four weeks after the second implant surgery, biopsies were obtained and prepared for histological examination. RESULTS/CONCLUSION: The vertical dimensions of the epithelial and connective tissue components as well as the composition of the connective tissue portion facing the implant were similar at collagen-coated and uncoated implants after 4 and 8 weeks of healing. It is suggested that soft tissue healing to implants coated with type I collagen was similar to that at non-coated titanium implants and that no adverse reactions to the collagen-coated implants occurred.

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