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B cells pulsed with Helicobacter pylori antigen efficiently activate memory CD8+ T cells from H. pylori-infected individuals

Journal article
Authors Josef Azem
Ann-Mari Svennerholm
Samuel B Lundin
Published in Clin Immunol
Volume 118
Issue 2-3
Pages 284-91
Publication year 2005
Published at Institute of Medical Microbiology/Immunology
Pages 284-91
Language en
Links dx.doi.org/10.1016/j.clim.2005.09.0...
Keywords Adult, Antigens, Bacterial/immunology/*physiology, B-Lymphocyte Subsets/*immunology/*microbiology, CD8-Positive T-Lymphocytes/*immunology, Cell Proliferation, Cells, Cultured, Gastric Mucosa/immunology/microbiology, Helicobacter Infections/*immunology, Helicobacter pylori/*immunology, Humans, *Immunologic Memory, Middle Aged, Monocytes/immunology
Subject categories Medical and Health Sciences

Abstract

Helicobacter pylori infection causes chronic gastritis that may progress to peptic ulcers or gastric adenocarcinoma and thereby cause major world-wide health problems. Previous studies have shown that CD4+ T cells are important in the immune response to H. pylori in humans, but the role of CD8+ T cells is less clear. In order to study the CD8+ T cell response to H. pylori in greater detail, we have evaluated efficient conditions for activation of CD8+ T cells in vitro. We show that H. pylori-reactive CD8+ T cells can be activated most efficiently by B cells or dendritic cells pulsed with H. pylori antigens. We further show that the majority of CD8+ T cells in H. pylori-infected gastric mucosa are memory cells, and that memory CD8+ T cells sorted from peripheral blood of H. pylori-infected individuals respond 15-fold more to H. pylori urease compared to memory cells from uninfected subjects. We conclude that CD8+ T cells do participate in the immune response to H. pylori, and this may have implications for the development of more severe disease outcomes in H. pylori-infected subjects.

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