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Detection of antibodies to toxin-coregulated pili in sera from cholera patients

Journal article
Authors Stephen Attridge
Gun Wallerström
Firdausi Qadri
Ann-Mari Svennerholm
Published in Infect Immun
Volume 72
Issue 3
Pages 1824-7
Publication year 2004
Published at Institute of Medical Microbiology/Immunology
Pages 1824-7
Language en
Links dx.doi.org/10.1128/IAI.72.3.1824-18...
Keywords Animals, Antibodies, Bacterial/administration & dosage/*blood, Antibodies, Monoclonal/administration & dosage, Antibody Specificity, Antigens, Bacterial, Bacterial Toxins/antagonists & inhibitors/*immunology, Cholera/*immunology/microbiology/prevention & control, Cholera Vaccines/administration & dosage, Fimbriae, Bacterial/*immunology, Humans, Mice, Vibrio cholerae O1/*immunology
Subject categories Medical and Health Sciences

Abstract

Monoclonal antibodies (MAbs) were prepared against toxin-coregulated pili (TCP) isolated from Vibrio cholerae O1 El Tor. Despite their limited bactericidal potential, two MAbs were able to mediate biotype-specific protection against experimental cholera in infant mice. These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients.

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