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Leukemia inhibitory factor reduces body fat mass in ovariectomized mice

Journal article
Authors John-Olov Jansson
Sofia Movérare-Skrtic
Anna Berndtsson
Ingrid Wernstedt
Hans Carlsten
Claes Ohlsson
Published in Eur J Endocrinol
Volume 154
Issue 2
Pages 349-54
ISSN 0804-4643 (Print)
Publication year 2006
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Medicine, Department of Internal Medicine
Pages 349-54
Language en
Keywords Adipose Tissue/*drug effects, Adipose Tissue, Brown/metabolism, Animals, Body Composition/drug effects, Body Weight/drug effects, Densitometry, X-Ray, Female, Interleukin-6/*pharmacology, Leptin/blood, Leukemia Inhibitory Factor, Mice, Mice, Inbred C57BL, Obesity/blood/*drug therapy/metabolism, Organ Size/drug effects, Ovariectomy, Tomography, X-Ray Computed
Subject categories Medical and Health Sciences


OBJECTIVE: Ovariectomized (OVX) mice are known to gain body fat while exposure to estrogens decreases fat mass. We have previously shown that estrogen replacement therapy enhances the expression of receptors for the cytokine, leukemia inhibitory factor (LIF). LIF and other cytokines acting via the gp130 signal transducing receptor have been reported to decrease obesity. In the present study, we investigated whether LIF treatment can reduce obesity in OVX mice. DESIGN: Eight-week-old female C57Bl/6 mice were OVX or sham-operated. The mice were treated with LIF, 30 microg/kg or PBS via daily i.p. injections for 15 days (n = 9-10). METHODS: Dual X-ray absorptiometry and computerized tomography. RESULTS: We found that LIF treatment of OVX mice caused a significant reduction in the weight of white fat depots (P = 0.017) and serum leptin levels (P = 0.011). LIF also caused a significant decrease in brown fat mass (P = 0.036). Treatment with LIF decreased thymus weight but did not affect crown-rump length, femur length, trabecular bone mineral density or the weight of several non-fat organs including the uterus. CONCLUSION: The cytokine, LIF, decreases body fat mass in OVX mice, suggesting that estrogen signaling is not required for this effect.

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