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Increased levels of circulating soluble CD14 but not CD83 in infants are associated with early intestinal colonization with Staphylococcus aureus

Journal article
Authors Anna-Carin Lundell
Ingegerd Adlerberth
Erika Lindberg
Helen Karlsson
Sofia Ekberg
Nils Åberg
Robert Saalman
Barry Hock
A. Steinkasserer
Bill Hesselmar
Agnes E Wold
Anna Rudin
Published in Clin Exp Allergy
Volume 37
Issue 1
Pages 62-71
Publication year 2007
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Biomedicine, Department of Infectious Medicine
Institute of Clinical Sciences
Pages 62-71
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Antigens, CD/*blood, Antigens, CD14/*blood, Biological Markers/blood, Case-Control Studies, Female, Food Hypersensitivity/immunology/microbiology, Humans, Hypersensitivity/immunology/*microbiology, Immunoglobulin E/blood, Immunoglobulins/*blood, Infant, Newborn, Intestines/*immunology/microbiology, Longitudinal Studies, Male, Membrane Glycoproteins/*blood, *Staphylococcus aureus, Statistics, Nonparametric
Subject categories Microbiology in the medical area, Allergology

Abstract

BACKGROUND: Soluble forms of the monocyte marker CD14 and the mature dendritic cell marker CD83 are plasma proteins with immunoregulatory functions. The physiological stimulus for their production is unclear and their possible role in allergy development is unknown. METHODS: We measured the plasma levels of soluble CD14 (sCD14) and soluble CD83 (sCD83) in 64 Swedish children in relation to intestinal bacterial colonization pattern in a prospective birth cohort. Soluble CD14 and sCD83 levels were quantified by enzyme linked immunosorbent assay in plasma obtained at birth and at 4, 18 and 36 months of age. All major aerobic and anaerobic bacteria were quantified in faecal samples obtained regularly over the first 8 weeks of life. Clinical allergy and IgE levels were evaluated at 18 months of age. RESULTS: Soluble CD14 in plasma increased during the first 18 months of life while sCD83 peaked at 4 months of age. Children who were perinatally colonized with Staphylococcus aureus had significantly higher levels of sCD14 in plasma at 4 months of age relative to non-colonized children. The levels of sCD14 were unrelated to colonization with Escherichia coli, other enterobacteria, enterococci, clostridia, Bacteroides, bifidobacteria or lactobacilli. Further, children with food allergy by 18 months tended to have lower levels of sCD14 than healthy children. Plasma levels of sCD83 were not related to either bacterial colonization pattern or allergy development. CONCLUSIONS: Perinatal colonization with S. aureus may trigger the occurrence of sCD14 in plasma, which may influence development of the infantile immune system and risk of allergy development.

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