To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Increased levels of acyla… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Increased levels of acylation-stimulating protein in interleukin-6-deficient (IL-6(-/-)) mice

Journal article
Authors Ingrid Wernstedt
Bob Olsson
Margareta Jernås
S. Paglialunga
Lena M S Carlsson
Ulf Smith
K. Cianflone
Kristina Wallenius
Ville Wallenius
Published in Endocrinology
Volume 147
Issue 6
Pages 2690-5
ISSN 0013-7227 (Print)
Publication year 2006
Published at Wallenberg Laboratory
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 2690-5
Language en
Keywords Adipocytes/pathology, Adipose Tissue/metabolism, Animals, Body Weight, Complement C3/metabolism, Complement C3a/*analysis/metabolism, Fatty Acids, Nonesterified/blood, Female, Interleukin-6/*physiology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Prealbumin/genetics, Properdin/genetics, Triglycerides/biosynthesis
Subject categories Medical and Health Sciences


IL-6-deficient (IL-6(-/-)) mice develop obesity at 6-7 months of age. To elucidate the mechanisms of this mature-onset obesity, global gene expression profiles of 3-month-old preobese IL-6(-/-) were compared with those of IL-6(+/+) mice using DNA arrays. Genes that were up-regulated in IL-6(-/-) mice included the factors transthyretin and properdin in white adipose tissue and adipsin in muscle. These factors have been shown to influence the formation of acylation-stimulating protein (ASP), a cleavage product of complement C3. ASP stimulates the synthesis of triacylglycerol in adipocytes, and ASP-deficient mice are resistant to diet-induced obesity. In line with the increases in transthyretin, properdin, and adipsin, ASP levels in serum were increased by 31-54% in IL-6(-/-) compared with IL-6(+/+) mice. Furthermore, IL-6 replacement treatment in IL-6(-/-) mice decreased ASP levels significantly by 25-60%. In conclusion, ASP levels are increased in preobese IL-6(-/-) mice. This increase may result in increased triacylglycerol formation and uptake in IL-6(-/-) adipocytes and thereby contribute to the development of obesity in IL-6(-/-) mice.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?