To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Plasma cells and Fc recep… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes

Journal article
Authors Jenny Palming
Britt G. Gabrielsson
Eva Jennische
Ulf Smith
Björn Carlsson
Lena M S Carlsson
Malin Lönn
Published in Biochem Biophys Res Commun
Volume 343
Issue 1
Pages 43-8
ISSN 0006-291X
Publication year 2006
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 43-8
Language en
Keywords Adipocytes/immunology, Adipose Tissue/*cytology/*immunology, Adult, Cell Count, Cytokines/genetics, Female, Gene Expression, Humans, Immunoglobulins/*genetics, Lipid Metabolism/immunology, Male, Oligonucleotide Array Sequence Analysis, Omentum/cytology, Plasma Cells/*immunology, Receptors, Fc/*analysis/*genetics
Subject categories Medical and Health Sciences


We have previously reported high immunoglobulin expression in human omental adipose tissue. The aim of this work was to investigate plasma cell density and Fc receptor (FcR) expression in human adipose tissue depots and in vitro effects of immunoglobulins on adipocyte function. Plasma cell density was higher in the visceral compared to the subcutaneous depot (10.0+/-1.56% and 5.2+/-0.98%, respectively, n=20, p<0.05). Microarray analysis revealed expression of four FcR genes in adipose tissue; FCGR2A, FCGR2B, FCER1G, and FCGRT. FCGR2A was highly expressed in adipocytes in both depots and this was verified by immunohistochemistry. Expression of IL-1beta and IL-6 was markedly reduced in adipocytes after incubation with the Fc moiety of immunoglobulin G (Fc) (p<0.01). Furthermore, Fc stimulated adipocyte lipogenesis as potently as insulin (p<0.05), but did not influence lipolysis. In conclusion, immunoglobulins produced by plasma cells in human adipose tissue could influence adipocyte metabolism and cytokine production.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?