To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Exopolysaccharides from B… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species

Journal article
Authors Johan Bylund
L. A. Burgess
P. Cescutti
R. K. Ernst
D. P. Speert
Published in J Biol Chem
Volume 281
Issue 5
Pages 2526-32
Publication year 2006
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 2526-32
Language en
Keywords Burkholderia/*chemistry/immunology/pathogenicity, Chemotaxis/*drug effects, Free Radical Scavengers, Humans, Immunity, Natural, Neutrophils/drug effects/*immunology, Polysaccharides, Bacterial/*pharmacology, Reactive Oxygen Species/antagonists & inhibitors/*metabolism
Subject categories Medical and Health Sciences


Bacteria belonging to the Burkholderia cepacia complex are important opportunistic pathogens in compromised hosts, particularly patients with cystic fibrosis or chronic granulomatous disease. Isolates of B. cepacia complex may produce large amounts of exopolysaccharides (EPS) that endow the bacteria with a mucoid phenotype and appear to facilitate bacterial persistence during infection. We showed that EPS from a clinical B. cenocepacia isolate interfered with the function of human neutrophils in vitro; it inhibited chemotaxis and production of reactive oxygen species (ROS), both essential components of innate neutrophil-mediated host defenses. These inhibitory effects were not due to cytotoxicity or interference with intracellular calcium signaling. EPS also inhibited enzymatic generation of ROS in cell-free systems, indicating that it scavenges these bactericidal products. B. cenocepacia EPS is structurally distinct from Pseudomonas aeruginosa alginate, yet they share the capacity to scavenge ROS and inhibit chemotaxis. These properties could explain why the two bacterial species resist clearance from the infected cystic fibrosis lung.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?