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Proteomic analysis using protein chips to detect biomarkers in cervical and amniotic fluid in women with intra-amniotic inflammation

Journal article
Authors Ulla Rüetschi
Åsa Rosen
Gösta Karlsson
Henrik Zetterberg
Lars Rymo
Henrik Hagberg
Bo Jacobsson
Published in J Proteome Res
Volume 4
Issue 6
Pages 2236-42
Publication year 2005
Published at Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
Pages 2236-42
Language en
Keywords Amniocentesis, Amnion/metabolism, Amniotic Fluid/chemistry/*metabolism, Biological Markers/*chemistry, Calgranulin A/metabolism, Calgranulin B/metabolism, Cervix Uteri/metabolism, Female, Fetal Membranes, Premature Rupture, *Gene Expression Regulation, Humans, Inflammation/*diagnosis, Mass Spectrometry, Neutrophils/metabolism, Obstetric Labor, Premature, Pregnancy, Pregnancy Complications, Premature Birth/*diagnosis/*metabolism, Protein Array Analysis/*methods, Proteins/chemistry, Proteome/chemistry, Proteomics/*methods, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Subject categories Medical and Health Sciences


Intra-amniotic inflammation (IAI) may cause preterm birth with poor neonatal out-come. To identify novel biomarkers for IAI, we analyzed amniotic and cervical fluid samples from 27 patients with signs of threatening preterm birth with or without IAI by surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Seventeen proteins were significantly overexpressed in amniotic fluid from IAI cases and more often in women with preterm labor than those with rupture of membranes. Five of these were identified as human neutrophil protein 1-3, calgranulin A and B.

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