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Prostate cancer progression into androgen independency is associated with alterations in cell adhesion and invasivity.

Journal article
Authors Karin Jennbacken
Helene Gustavsson
Karin Welén
Christina Vallbo
Jan-Erik Damber
Published in Prostate
Volume 66
Issue 15
Pages 1631-1640
Publication year 2006
Published at Institute of Clinical Sciences
Pages 1631-1640
Language en
Links dx.doi.org/10.1002/pros.20469
Keywords LNCaP • androgen independent • hormone refractory • cadherin • integrin • MMP
Subject categories Urology and andrology

Abstract

Background Mortality in prostate cancer is primarily due to failure to cure hormone refractory patients with metastatic disease. The present study focused on elucidating alterations in invasive properties, which are connected with progression into androgen independency. Methods Ability to grow without anchor, migration, cell adhesion properties and expression of invasive factors were investigated in LNCaP and its androgen-independent subline LNCaP-19. Also, invasive capacity into blood vessels was examined in subcutaneous tumors. Results Transition into an androgen-independent state was associated with ability to grow without anchor, increased migration, and alterations in cell adhesion properties. The tumor suppressor E-cadherin was downregulated and the proinvasive factors N-cadherin, MMP-9, and membrane type 1 (MT1)-MMP were upregulated in LNCaP-19. In addition, LNCaP-19 displayed a markedly increased invasivity into blood vessels. Conclusions The results show that LNCaP-19 mimics hormone refractory prostate cancer and therefore is an excellent tool for studies on androgen-independent cancer and invasion. This study shows that transition into an androgen-independent state correlates with several proinvasive alterations. Prostate 66: 1631-1640, 2006. © 2006 Wiley-Liss, Inc.

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