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Torsional stiffness in healing fractures: influence of ossification: an experimental study in rats

Journal article
Authors Hans Mark
Björn Rydevik
Published in Acta orthopaedica
Volume 76
Issue 3
Pages 428-33
ISSN 1745-3674 (Print)
Publication year 2005
Published at Institute of Surgical Sciences, Department of Plastic Surgery
Institute of Surgical Sciences, Department of Orthopaedics
Pages 428-33
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Animals, Biomechanics, Femoral Fractures/*physiopathology/surgery, Fracture Fixation/*methods, Fracture Healing/*physiology, Osteogenesis/*physiology, Rats, Rats, Sprague-Dawley, Torsion
Subject categories Orthopaedics

Abstract

BACKGROUND: Different fracture fixation techniques and fracture environment influence bone formation in healing fractures. However, the influence on the development of biomechanical properties has not been clear described. We evaluated the influence of fracture fixation stability and fracture environment on mechanical properties in healing femoral fractures in rats. METHODS: Animals were treated surgically with external fixation: 1 group (27 rats) with 0-mm fracture gap size with bone ends touching, corresponding to an axial stiffness of 265 (SD 34) N/mm, and a second group (27 rats) with 2-mm fracture gap size corresponding to an axial stiffness of 30 (SD 2.1) N/mm. From each group, 6-7 animals were killed at 2, 4, 6 and 12 weeks. Torsional test revealed a delay in torsional stiffness in fractures in group 2 compared to group 1. In group 2, the torsional stiffness of the contralateral femora was found to be greater at 12 weeks than the torsional stiffness in group 1. INTERPRETATION: We found that during fracture healing, the development of torsional stiffness corresponds to the magnitude of endochondral ossification and late response of bone formation. A significantly increased torsional stiffness in the non-fractured leg of rats with delayed fracture healing was also found, possibly indicating a response to loading conditions or a systemic stimulation of bone mass.

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