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Inverse relationship between central serotonergic neurotransmission and blood pressure in alcohol-dependent male subjects

Journal article
Authors Jan Balldin
Madelene Andersson
Ulf Berggren
Jörgen Engel
Matts Eriksson
Claudia Fahlke
Published in Journal of Neural Transmission
Volume 113
Pages 1511-1517
Publication year 2006
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Department of Psychology
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 1511-1517
Language en
Keywords Alcohol-dependence, blood pressure, CNS, serotonin
Subject categories Pharmacology, Psychology

Abstract

Data has accumulated indicating an inverse relation between central serotonergic (5-HT) neurotransmission and blood pressure in hypertensive rats and in healthy individuals. The present study aimed to elucidate whether an inverse relation exists between systolic (SBP) and diastolic (DBP) blood pressure levels and central 5-HT neurotransmission also in a group of alcohol-dependent individuals. Central 5-HT neurotransmission was assessed by using the maximum prolactin (PRL) responses to the 5-HT probe DL-fenfluramine (DL-FEN; 60 mg po.) in 17 alcohol-dependent male subjects investigated during a period of on-going alcohol intake. BP was measured immediately before all time points for blood sampling, and readings before DL-FEN administration were used as the subjects resting BP. Results showed that there were inverse correlations between the maximum PRL responses to DL-FEN and the SBP levels (r = -0.57, p < 0.002) and with the DBP levels (r = -0.52, p < 0.05), respectively. The present study suggests the existence of an association between central 5-HT neurotransmission and blood pressure regulation also in alcohol-dependent individuals.

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