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Type 2 diabetes mellitus contributes to cognitive change in the oldest old: A longitudinal population-based study

Journal article
Authors Linda Hassing
M. D Grant
S. M Hofer
N. L Pedersen
S. E Nilsson
S Berg
G McClearn
Boo Johansson
Published in Journal of the International Neuropsychological Society
Issue 10
Pages 599-607
Publication year 2004
Published at Department of Psychology
Pages 599-607
Language en
Keywords Diabetes, dementia, old age, cognitive decline, longitudinal study
Subject categories Psychology

Abstract

We examined change in neuropsychological test performance related to type 2 diabetes mellitus across a 6-year interval. A population-based sample of 274 elderly participants (36 with diabetes and 238 without diabetes) was examined at four occasions at a 2-year interval. The participants were 80–93 years of age (M 5 82.8 years) and without dementia at baseline. The test battery included tests of speed, visuospatial ability, short-term memory, semantic memory, episodic memory, and the Mini Mental Status Examination. Several models, taking into account diabetes and demographic data, were analyzed using SAS Proc Mixed multilevel modeling. At baseline, there were no significant differences in the neuropsychological tests related to diabetes. The longitudinal analyses, however, showed that diabetes was a significant predictor of decline for many of the tests. These findings points to the conclusion that type 2 diabetes is associated with accelerated cognitive decline in old age that may result in dementia.

Page Manager: Webmaster|Last update: 9/11/2012
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