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Rare non-Hodgkin lymphoma of childhood and adolescence: A consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma

Journal article
Authors A. Attarbaschi
O. Abla
L. A. Padilla
A. Beishuizen
G. A. A. Burke
L. Brugieres
J. Bruneau
B. Burkhardt
E. S. G. d'Amore
W. Klapper
U. Kontny
M. Pillon
M. Taj
S. D. Turner
A. Uyttebroeck
W. Woessmann
Karin Mellgren
Published in Pediatric Blood & Cancer
Volume 67
Issue 8
ISSN 1545-5009
Publication year 2020
Published at Institute of Clinical Sciences, Department of Pediatrics
Language en
Subject categories Pediatrics, Cancer and Oncology


Pediatric-type follicular (PTFL), marginal zone (MZL), and peripheral T-cell lymphoma (PTCL) account each for <2% of childhood non-Hodgkin lymphoma. We present clinical and histopathological features of PTFL, MZL, and few subtypes of PTCL and provide treatment recommendations. For localized PTFL and MZL, watchful waiting after complete resection is the therapy of choice. For PTCL, therapy is subtype-dependent and ranges from a block-like anaplastic large cell lymphoma (ALCL)-derived and, alternatively, leukemia-derived therapy in PTCL not otherwise specified and subcutaneous panniculitis-like T-cell lymphoma to a block-like mature B-NHL-derived or, preferentially, ALCL-derived treatment followed by hematopoietic stem cell transplantation in first remission in hepatosplenic and angioimmunoblastic T-cell lymphoma.

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