To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

An Imbalance of the Immun… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

An Imbalance of the Immune System Instead of a Disease Behind Marginal Bone Loss Around Oral Implants: Position Paper

Journal article
Authors Tomas Albrektsson
Christer Dahlin
David Reinedahl
Pentti Tengvall
Ricardo Trindade
Ann Wennerberg
Published in The International journal of oral & maxillofacial implants
Volume 35
Issue 3
Pages 495-502
Publication year 2020
Published at Institute of Odontology
Institute of Odontology, Section 2
Institute of Clinical Sciences, Department of Biomaterials
Pages 495-502
Language en
Keywords biomaterials, failure analysis, immunologic reactions, peri-implantitis, review (narrative)
Subject categories Biomaterials Science, Medical Biotechnology, Basic Medicine


PURPOSE: The purpose of this paper is to present evidence that supports the notion that the primary reason behind marginal bone loss and implant failure is immune-based and that bacterial actions in the great majority of problematic cases are of a secondary nature. MATERIALS AND METHODS: The paper is written as a narrative review. RESULTS: Evidence is presented that commercially pure titanium is not biologically inert, but instead activates the innate immune system of the body. For its function, the clinical implant is dependent on an immune/inflammatory defense against bacteria. Biologic models such as ligature studies have incorrectly assumed that the primary response causing marginal bone loss is due to bacterial action. In reality, bacterial actions are secondary to an imbalance of the innate immune system caused by the combination of titanium implants and ligatures, ie, nonself. This immunologic imbalance may lead to marginal bone resorption even in the absence of bacteria. CONCLUSION: Marginal bone loss and imminent oral implant failure cannot be properly analyzed without a clear understanding of immunologically caused tissue responses.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?