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Imaging biomarkers in neurodegeneration: current and future practices.

Review article
Authors Peter N E Young
Mar Estarellas
Emma Coomans
Meera Srikrishna
Helen Beaumont
Anne Maass
Ashwin V Venkataraman
Rikki Lissaman
Daniel Jiménez
Matthew J Betts
Eimear McGlinchey
David Berron
Antoinette O'Connor
Nick C Fox
Joana B Pereira
William Jagust
Stephen F Carter
Ross W Paterson
Michael Schöll
Published in Alzheimer's research & therapy
Volume 12
Issue 1
ISSN 1758-9193
Publication year 2020
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Wallenberg Centre for Molecular and Translational Medicine
Language en
Links dx.doi.org/10.1186/s13195-020-00612...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Clinical Medicine, Basic Medicine, Medical Biotechnology

Abstract

There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigation of neurodegenerative disorders has increased substantially over the past decades and continues to provide further benefits both to the diagnosis and understanding of these diseases. This review forms part of a series of articles which stem from the University College London/University of Gothenburg course "Biomarkers in neurodegenerative diseases". In this review, we focus on neuroimaging, specifically positron emission tomography (PET) and magnetic resonance imaging (MRI), giving an overview of the current established practices clinically and in research as well as new techniques being developed. We will also discuss the use of machine learning (ML) techniques within these fields to provide additional insights to early diagnosis and multimodal analysis.

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