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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Review article
Authors Nicholas J. Ashton
Abdul Hye
Anto P Rajkumar
Antoine Leuzy
Stuart Snowden
Marc Suárez-Calvet
Thomas Karikari
Michael Schöll
Renaud La Joie
Gil D Rabinovici
Kina Höglund
Clive Ballard
Tibor Hortobágyi
Per Svenningsson
Kaj Blennow
Henrik Zetterberg
Dag Aarsland
Published in Nature Reviews Neurology
Volume 16
Pages 265–284
ISSN 1759-4766
Publication year 2020
Published at Wallenberg Laboratory
Institute of Neuroscience and Physiology, Department of Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Wallenberg Centre for Molecular and Translational Medicine
Pages 265–284
Language en
Links dx.doi.org/10.1038/s41582-020-0348-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Basic Medicine

Abstract

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-sensitive assays have enabled the levels of pathological proteins to be measured in blood samples, but research has been predominantly focused on Alzheimer disease (AD). Nonetheless, proteins that were identified as potential blood-based biomarkers for AD, for example, amyloid-β, tau, phosphorylated tau and neurofilament light chain, are likely to be relevant to other neurodegenerative disorders that involve similar pathological processes and could also be useful for the differential diagnosis of clinical symptoms. This Review outlines the neuropathological, clinical, molecular imaging and cerebrospinal fluid features of the most common neurodegenerative disorders outside the AD continuum and gives an overview of the current status of blood-based biomarkers for these disorders.

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