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Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease.

Journal article
Authors Kunal Dhiman
Veer Bala Gupta
Victor L Villemagne
Dhamidhu Eratne
Petra L Graham
Christopher Fowler
Pierrick Bourgeat
Qiao-Xin Li
Steven Collins
Ashley I Bush
Christopher C Rowe
Colin L Masters
David Ames
Eugene Hone
Kaj Blennow
Henrik Zetterberg
Ralph N Martins
Published in Alzheimer's & dementia (Amsterdam, Netherlands)
Volume 12
Issue 1
Pages e12005
ISSN 2352-8729
Publication year 2020
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages e12005
Language en
Links dx.doi.org/10.1002/dad2.12005
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry

Abstract

This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology, as well as its potential to predict brain atrophy, cognition, and amyloid accumulation.CSF NfL concentration was measured in 221 participants from the Australian Imaging, Biomarkers & Lifestyle Flagship Study of Ageing (AIBL).CSF NfL levels as well as NfL/amyloid β (Aβ42) were significantly elevated in AD compared to healthy controls (HC; P < .001), and in mild cognitive impairment (MCI) compared to HC (P = .008 NfL; P < .001 NfL/Aβ42). CSF NfL and NfL/Aβ42 differentiated AD from HC with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.84 and 0.90, respectively. CSF NfL and NfL/Aβ42 predicted cortical amyloid load, brain atrophy, and cognition.CSF NfL is a biomarker of neurodegeneration, correlating with cognitive impairment and brain neuropathology.

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