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B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.

Journal article
Authors Adi Biram
Eitan Winter
Alice E Denton
Irina Zaretsky
Bareket Dassa
Mats Bemark
Michelle A Linterman
Gur Yaari
Ziv Shulman
Published in Cell reports
Volume 30
Issue 6
Pages 1910-1922.e5
ISSN 2211-1247
Publication year 2020
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 1910-1922.e5
Language en
Links dx.doi.org/10.1016/j.celrep.2020.01...
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Mucosal Immunology, Peyer's patches, Germinal center, IgA
Subject categories Immunology in the medical area, Immunology

Abstract

Antibodies secreted within the intestinal tract provide protection from the invasion of microbes into the host tissues. Germinal center (GC) formation in lymph nodes and spleen strictly requires SLAM-associated protein (SAP)-mediated T cell functions; however, it is not known whether this mechanism plays a similar role in mucosal-associated lymphoid tissues. Here, we find that in Peyer's patches (PPs), SAP-mediated T cell help is required for promoting B cell selection in GCs, but not for clonal diversification. PPs of SAP-deficient mice host chronic GCs that are absent in T cell-deficient mice. GC B cells in SAP-deficient mice express AID and Bcl6 and generate plasma cells in proportion to the GC size. Single-cell IgA sequencing analysis reveals that these mice host few diversified clones that were subjected to mild selection forces. These findings demonstrate that T cell-derived help to B cells in PPs includes SAP-dependent and SAP-independent functions.

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