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Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

Journal article
Authors Y. A. An
C. Crewe
Ingrid Wernstedt Asterholm
K. Sun
S. W. Chen
F. Zhang
M. L. Shao
J. B. Funcke
Z. Z. Zhang
L. Straub
J. Yoshino
S. Klein
C. M. Kusminski
P. E. Scherer
Published in Nature Metabolism
Volume 1
Issue 12
Pages 1243-57
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 1243-57
Language en
Links dx.doi.org/10.1038/s42255-019-0149-...
Keywords insulin sensitivity, alzheimers-disease, dysfunction, import, inflammation, adipocytes, inhibition, expression, energy, Endocrinology & Metabolism
Subject categories Endocrinology and Diabetes

Abstract

Mitochondrial function in white adipose tissue (WAT) is an important yet understudied aspect of adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in compromising WAT mitochondrial function through a high-fat diet (HFD)-induced, unconventional mis-localization to mitochondria that further promotes obesity. In humans and mice, obese conditions induce substantial APP production in WAT and APP enrichment in mitochondria. Mechanistically, HFD-induced dysregulation of signal recognition particle subunit 54c is responsible for the mis-targeting of APP to adipocyte mitochondria. Mis-localized APP blocks the protein import machinery, leading to mitochondrial dysfunction in WAT. Mice overexpressing adipocyte-specific and mitochondria-targeted APP display increased body mass and reduced insulin sensitivity, along with dysfunctional WAT, owing to a dramatic hypertrophic program in adipocytes. Elimination of adipocyte APP rescues HFD-impaired mitochondrial function with considerable protection from weight gain and systemic metabolic deficiency. Our data highlight an important role for APP in modulating WAT mitochondrial function and obesity-associated metabolic dysfunction.

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