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Neural correlates of the DMT experience assessed with multivariate EEG

Journal article
Authors C. Timmermann
L. Roseman
M. Schartner
R. Milliere
L. T. J. Williams
D. Erritzoe
S. Muthukumaraswamy
Michael Ashton
Adam Bendrioua
O. Kaur
S. Turton
M. M. Nour
C. M. Day
R. Leech
D. J. Nutt
R. L. Carhart-Harris
Published in Scientific Reports
Volume 9
Pages 13
ISSN 2045-2322
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 13
Language en
Links dx.doi.org/10.1038/s41598-019-51974...
Keywords alpha oscillations, dose-response, n,n-dimethyltryptamine, underlies, ayahuasca, humans, states
Subject categories Clinical Medicine

Abstract

Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.

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