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High serum concentration of vitamin D may protect against multiple sclerosis

Journal article
Authors Martin Biström
Lucia Alonso-Magdalena
Oluf Andersen
Daniel Jons
Martin Gunnarsson
Magnus Vrethem
Johan Hultdin
Peter Sundström
Published in Multiple Sclerosis Journal - Experimental, Transitional and Clinical
Volume 5
Issue 4
Pages 1-5
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 1-5
Language en
Keywords Vitamin D, multiple sclerosis, case–control studies, risk factors, epidemiology, 25-hydroxyvitamin D
Subject categories Neurology


Background: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. Objective: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent. Methods: Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry. Results: High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93). Conclusion: These findings further support a role for vitamin D in MS aetiology.

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