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Hearing Status in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study.

Journal article
Authors Anne-Sofie Skou
Steen Ø Olsen
Lars H Nielsen
Heidi Glosli
Kirsi Jahnukainen
Marianne Jarfelt
Guðmundur K Jónmundsson
Johan Malmros
Karsten Nysom
Henrik Hasle
Published in Journal of pediatric hematology/oncology
Volume 41
Issue 1
Pages e12-e17
ISSN 1536-3678
Publication year 2019
Published at
Pages e12-e17
Language en
Keywords Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, administration & dosage, adverse effects, Cancer Survivors, Child, Child, Preschool, Female, Follow-Up Studies, Hearing, drug effects, Hearing Disorders, chemically induced, epidemiology, Humans, Infant, Infant, Newborn, Leukemia, Myeloid, Acute, drug therapy, epidemiology, Male, Retrospective Studies, Siblings
Subject categories Hematology, Audiology


As more children survive acute myeloid leukemia (AML) it is increasingly important to assess possible late effects of the intensive treatment. Hearing loss has only sporadically been reported in survivors of childhood AML. We assessed hearing status in survivors of childhood AML treated with chemotherapy alone according to 3 consecutive NOPHO-AML trials.A population-based cohort of children treated according to the NOPHO-AML-84, NOPHO-AML-88, and NOPHO-AML-93 trials included 137 eligible survivors among whom 101 (74%) completed a questionnaire and 99 (72%) had otologic and audiologic examination performed including otoscopy (72%), pure tone audiometry (70%), and tympanometry (60%). Eighty-four of 93 (90%) eligible sibling controls completed a similar questionnaire.At a median of 11 years (range, 4 to 25) after diagnosis, hearing disorders were rare in survivors of childhood AML and in sibling controls, with no significant differences. None had severe or profound hearing loss diagnosed at audiometry. Audiometry detected a subclinical hearing loss ranging from slight to moderate in 19% of the survivors, 5% had low-frequency hearing loss, and 17% had high-frequency hearing loss.The frequency of hearing disorders was low, and hearing thresholds in survivors of childhood AML were similar to background populations of comparable age.

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