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Does the antisecretory peptide AF-16 reduce lung oedema in experimental ARDS?

Journal article
Authors A. B. Tenhunen
F. Massaro
Hans-Arne Hansson
R. Feinstein
A. Larsson
G. Perchiazzi
Published in Upsala Journal of Medical Sciences
Pages 8
ISSN 0300-9734
Publication year 2019
Published at Institute of Biomedicine
Pages 8
Language en
Links dx.doi.org/10.1080/03009734.2019.16...
Keywords AF-16 antisecretory factor, ARDS, extravascular lung water, pulmonary, oedema, acute respiratory-distress, permeability, stress, strain
Subject categories Clinical Medicine

Abstract

Background: Acute respiratory distress syndrome (ARDS) is an acute inflammatory condition with pulmonary capillary leakage and lung oedema formation. There is currently no pharmacologic treatment for the condition. The antisecretory peptide AF-16 reduces oedema in experimental traumatic brain injury. In this study, we tested AF-16 in an experimental porcine model of ARDS. Methods: Under surgical anaesthesia 12 piglets were subjected to lung lavage followed by 2 hours of injurious ventilation. Every hour for 4 hours, measurements of extravascular lung water (EVLW), mechanics of the respiratory system, and hemodynamics were obtained. Results: There was a statistically significant (p = 0.006, two-way ANOVA) reduction of EVLW in the AF-16 group compared with controls. However, this was not mirrored in any improvement in the wet-to-dry ratio of lung tissue samples, histology, inflammatory markers, lung mechanics, or gas exchange. Conclusions: This pilot study suggests that AF-16 might improve oedema resolution as indicated by a reduction in EVLW in experimental ARDS.

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