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MicroRNA-155 expression suggests a sex disparity in innate lymphoid cells at the single-cell level

Journal article
Authors Carina Malmhäll
Julie Weidner
Madeleine Rådinger
Published in Cellular and Molecular Immunology
ISSN 1672-7681
Publication year 2019
Published at Krefting Research Centre
Language en
Links doi.org/10.1038/s41423-019-0303-4
Keywords microRNA-155, PrimeFlow, sex differences, astma
Subject categories Basic Medicine

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression at the post-transcriptional level, thereby serving as important cellular regulators.1 However, miRNA expression in specific human cellular subtypes, especially at the single-cell level, remains largely unexplored. In this study, a novel method called the PrimeFlow™ RNA Assay2 was used to directly monitor miRNA expression in the cell. Notably, we demonstrate for the first time that human innate lymphoid cells (ILCs) express miR-155. We further demonstrate a clear distinction between the sexes, with a significant increase in the number of ILCs expressing miR-155 in female-derived cells compared with male-derived cells upon in vitro stimulation.

Page Manager: Webmaster|Last update: 9/11/2012
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