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Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Journal article
Authors Meenu Rohin Rajan
Matus Sotak
Fredrik Barrenäs
Tong Shen
Kamil Borkowski
Nicholas J Ashton
Christina Biörserud
Tomas L Lindahl
Sofia Ramström
Michael Schöll
Per Lindahl
Oliver Fiehn
John W Newman
Rosie Perkins
Ville Wallenius
Stephan Lange
Emma Börgeson
Published in Scientific reports
Volume 9
Issue 1
ISSN 2045-2322
Publication year 2019
Published at Wallenberg Laboratory
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Medicine
Wallenberg Centre for Molecular and Translational Medicine
Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
Institute of Clinical Sciences
Language en
Links dx.doi.org/10.1038/s41598-019-51673...
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Biomarkers, obesity, cardiometabolic disease, Olink
Subject categories Basic Medicine, Clinical Medicine

Abstract

The search for biomarkers associated with obesity-related diseases is ongoing, but it is not clear whether plasma and serum can be used interchangeably in this process. Here we used high-throughput screening to analyze 358 proteins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and serum from age- and sex-matched lean and obese humans. Most of the proteins/lipids had similar concentrations in plasma and serum, but a subset showed significant differences. Notably, a key marker of cardiovascular disease PAI-1 showed a difference in concentration between the obese and lean groups only in plasma. Furthermore, some biomarkers showed poor correlations between plasma and serum, including PCSK9, an important regulator of cholesterol homeostasis. Collectively, our results show that the choice of biofluid may impact study outcome when screening for obesity-related biomarkers and we identify several markers where this will be the case.

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