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Sector-wise golden-angle phase contrast with high temporal resolution for evaluation of left ventricular diastolic dysfunction

Journal article
Authors A. Fyrdahl
J. G. Ramos
M. J. Eriksson
Kenneth Caidahl
M. Ugander
A. Sigfridsson
Published in Magnetic Resonance in Medicine
Volume 83
Issue 4
Pages 1310-1321
ISSN 0740-3194
Publication year 2020
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1310-1321
Language en
Links dx.doi.org/10.1002/mrm.28018
Keywords diastolic dysfunction, golden angle, phase contrast, reconstruction, mri, improve, Radiology, Nuclear Medicine & Medical Imaging
Subject categories Radiology, Nuclear Medicine and Medical Imaging

Abstract

Purpose To develop a high temporal resolution phase‐contrast pulse sequence for evaluation of diastolic filling patterns, and to evaluate it in comparison to transthoracic echocardiography. Methods A phase‐contrast velocity‐encoded gradient‐echo pulse sequence was implemented with a sector‐wise golden‐angle radial ordering. Acquisitions were optimized for myocardial tissue (TE/TR: 4.4/6.8 ms, flip angle: 8º, velocity encoding: 30 cm/s) and transmitral flow (TE/TR: 4.0/6.6 ms, flip angle: 20º, velocity encoding: 150 cm/s). Shared velocity encoding was combined with a sliding‐window reconstruction that enabled up to 250 frames per cardiac cycle. Transmitral and myocardial velocities were measured in 35 patients. Echocardiographic velocities were obtained with pulsed‐wave Doppler using standard methods. Results Myocardial velocity showed a low difference and good correlation between MRI and Doppler (mean ± 95% limits of agreement 0.9 ± 3.7 cm/s, R2 = 0.63). Transmitral velocity was underestimated by MRI (P < .05) with a difference of −11 ± 28 cm/s (R2 = 0.45). The early‐to‐late ratio correlated well (R2 = 0.66) with a minimal difference (0.03 ± 0.6). Analysis of interobserver and intra‐observer variability showed excellent agreement for all measurements. Conclusions The proposed method enables the acquisition of phase‐contrast images during a single breath‐hold with a sufficiently high temporal resolution to match transthoracic echocardiography, which opens the possibility for many clinically relevant variables to be assessed by MRI.

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