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Mixed connective tissue disease with temporomandibular joint ankylosis: A case report

Journal article
Authors J. Sköldstam
B. Alsén
Christer Dahlin
Published in Oral and Maxillofacial Surgery Cases
Volume 5
Issue 3
ISSN 2214-5419
Publication year 2019
Published at Institute of Clinical Sciences, Department of Biomaterials
Language en
Keywords Ankylosis, Arthroplasty, Mixed connective tissue disease, Temporalis muscle flap, Temporomandibular joint, amitriptyline, corticosteroid, hydroxychloroquine, ibuprofen, mepenzolate, omeprazole, pregabalin, adult, arthrocentesis, Article, case report, clinical article, computer assisted tomography, female, follow up, histopathology, human, jaw pain, masticatory muscle, nuclear magnetic resonance imaging, priority journal, range of motion, temporalis muscle, temporomandibular ankylosis, visual analog scale
Subject categories Surgery


Mixed connective tissue disease (MCTD) is a rare systemic autoimmune disorder, which can affect the temporomandibular joint (TMJ). The literature on TMJ dysfunction in patients with MCTD is however sparse. This is a case report of a 35-year old woman with MCTD, who presented with severe pain from the temporomandibular region. She had a disc-derangement and intra-articular erosions of her left TMJ and developed a fibrous ankylosis of her right TMJ. The conditions led to arthroplasty with interposition of a temporalis muscle flap (TMF) bilaterally. Follow-up showed re-establishment of the cortical borders of the condyles and glenoid fossae and a pain free craniomandibular articulation within a normal range of motion. This is to our knowledge the first report on TMJ ankylosis and arthroplasty with the interposition of TMFs in a patient with MCTD. The report describes the clinical progression, the surgical intervention and presents a narrative review of the literature. © 2019

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