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Management of hepatitis B virus infection, updated Swedish guidelines.

Journal article
Authors Johan Westin
Soo Aleman
Maria Castedal
Ann-Sofi Duberg
Anders Eilard
Björn Fischler
Christian Kampmann
Karin Lindahl
Magnus Lindh
Gunnar Norkrans
Stephan Stenmark
Ola Weiland
Rune Wejstål
Published in Infectious diseases
Volume 52
Issue 1
Pages 1-22
ISSN 2374-4243
Publication year 2020
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Biomedicine, Department of Infectious Medicine
Pages 1-22
Language en
Subject categories Clinical Medicine


Despite access to effective antiviral drugs and vaccines, hepatitis B virus (HBV) infection remains a major health issue worldwide. HBV is highly infectious and may cause chronic infection, progressive liver damage, hepatocellular cancer (HCC) and death. Early diagnosis, proper management and timing of treatment are crucial. The Swedish Reference group for Antiviral Treatment (RAV) here provides updated evidence-based guidelines for treatment and management of HBV infection which may be applicable also in other countries. Tenofovir alafenamide (TAF) has been introduced as a novel treatment option and new principles regarding indication and duration of treatment and characterization of hepatitis B have been gradually introduced which justifies an update of the previous guidelines from 2007. Updated guidelines on HCC surveillance in HBV-infected patients, treatment and prophylaxis for patients undergoing liver transplantation as well as management of pregnant women and children with HBV infection are also provided.

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