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Dyslipidemia in retinal metabolic disorders

Journal article
Authors Z. J. Fu
C. T. Chen
G. Cagnone
E. Heckel
Y. Sun
B. Cakir
Y. Tomita
S. Huang
Q. Li
W. Britton
S. S. Cho
T. S. Kern
Ann Hellström
J. S. Joyal
L. E. H. Smith
Published in Embo Molecular Medicine
Volume 11
Issue 10
ISSN 1757-4676
Publication year 2019
Published at Institute of Neuroscience and Physiology
Language en
Keywords dyslipidemia, FGF21, photoreceptor, retinal metabolism, beta-oxidation, polyunsaturated fatty-acids, bevacizumab avastin therapy, genome-wide, association, macular degeneration, diabetic-retinopathy, beta-oxidation, choroidal neovascularization, cerebrovascular accidents, retinitis-pigmentosa, photoreceptor cells, Research & Experimental Medicine
Subject categories Clinical Medicine


The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.

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