To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Dyslipidemia in retinal m… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Dyslipidemia in retinal metabolic disorders

Journal article
Authors Z. J. Fu
C. T. Chen
G. Cagnone
E. Heckel
Y. Sun
B. Cakir
Y. Tomita
S. Huang
Q. Li
W. Britton
S. S. Cho
T. S. Kern
Ann Hellström
J. S. Joyal
L. E. H. Smith
Published in Embo Molecular Medicine
Volume 11
Issue 10
ISSN 1757-4676
Publication year 2019
Published at Institute of Neuroscience and Physiology
Language en
Links dx.doi.org/10.15252/emmm.201910473
Keywords dyslipidemia, FGF21, photoreceptor, retinal metabolism, beta-oxidation, polyunsaturated fatty-acids, bevacizumab avastin therapy, genome-wide, association, macular degeneration, diabetic-retinopathy, beta-oxidation, choroidal neovascularization, cerebrovascular accidents, retinitis-pigmentosa, photoreceptor cells, Research & Experimental Medicine
Subject categories Clinical Medicine

Abstract

The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?