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Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development

Journal article
Authors S. Mani
F. R. Toapanta
M. A. McArthur
F. Qadri
Ann-Mari Svennerholm
B. Devriendt
A. Phalipon
D. Cohen
M. B. Sztein
Published in Vaccine
Volume 37
Issue 34
Pages 4787-4793
ISSN 0264-410X
Publication year 2019
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 4787-4793
Language en
Links dx.doi.org/10.1016/j.vaccine.2019.0...
Keywords B cells, Correlates of protection (CoP), Enterotoxigenic Escherichia coli (ETEC), IgA, IgG, Immunocorrelate, Mucosal antibodies, Shigella, T cells
Subject categories Immunology

Abstract

The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop. © 2019

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