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Evaluation of a sensor algorithm for motor state rating in Parkinson's disease

Journal article
Authors Dongni Johansson
I. Thomas
A. Ericsson
A. Johansson
A. Medvedev
M. Memedi
D. Nyholm
F. Ohlsson
M. Senek
J. Spira
J. Westin
Filip Bergquist
Published in Parkinsonism & Related Disorders
Volume 64
Issue July
Pages 112-117
ISSN 1353-8020
Publication year 2019
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 112-117
Language en
Links dx.doi.org/10.1016/j.parkreldis.201...
Keywords Levodopa challenge test, Independent evaluation, Wearable sensors, Parkinson's disease, Machine, levodopa, fluctuations, reliability, dyskinesia, Neurosciences & Neurology
Subject categories Neurology

Abstract

Introduction: A treatment response objective index (TRIS) was previously developed based on sensor data from pronation-supination tests. This study aimed to examine the performance of TRIS for medication effects in a new population sample with Parkinson's disease (PD) and its usefulness for constructing individual dose-response models. Methods: Twenty-five patients with PD performed a series of tasks throughout a levodopa challenge while wearing sensors. TRIS was used to determine motor changes in pronation-supination tests following a single levodopa dose, and was compared to clinical ratings including the Treatment Response Scale (TRS) and six sub-items of the UPDRS part III. Results: As expected, correlations between TRIS and clinical ratings were lower in the new population than in the initial study. TRIS was still significantly correlated to TRS (r(s) = 0.23, P < 0.001) with a root mean square error (RMSE) of 1.33. For the patients (n = 17) with a good levodopa response and clear motor fluctuations, a stronger correlation was found (r(s) = 0.38, RMSE = 1.29, P < 0.001). The mean TRIS increased significantly when patients went from the practically defined off to their best on state (P = 0.024). Individual dose-response models could be fitted for more participants when TRIS was used for modelling than when TRS ratings were used. Conclusion: The objective sensor index shows promise for constructing individual dose-response models, but further evaluations and retraining of the TRIS algorithm are desirable to improve its performance and to ensure its clinical effectiveness.

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