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Preterm delivery: an overview on prediction, prevention and treatment

Journal article
Authors Bo Jacobsson
Sissel Saltvedt
Anna-Karin Wikström
Nils-Halvdan Morken
Åsa Leijonhufvud
Henrik Hagberg
Published in Läkartidningen
Volume 116
ISSN 1652-7518
Publication year 2019
Published at Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Language sv
Subject categories Obstetrics and gynaecology


Due to a low level of understanding of mechanisms involved in spontaneous preterm delivery there is a lack of reliable biomarkers. Existing biomarkers have a low positive predictive value but a high negative predictive value. Use of tests with high negative predictive value will reduce unnecessary interventions and hospitalization of women with threatening preterm delivery. When given to the right pregnant women, antenatal corticosteroid treatment are still the most important obstetrical intervention and reduces both neonatal mortality and short- and long-term morbidity.Several ongoing national Swedish multicenter studies may increase the understanding of the roles of cervical length, preeclampsia screening and magnesium sulfate dosage in the context of preterm delivery in a Nordic setting. Major development has been achieved in prediction and prevention of preterm preeclampsia at the cost of a 10% screen positive rate.

Page Manager: Webmaster|Last update: 9/11/2012

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