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Effects of Omega-3 Fatty Acids on Immune Cells

Journal article
Authors Saray Gutiérrez
Sara L Svahn
Maria E Johansson
Published in International Journal of Molecular Sciences
Volume 20
Issue 20
ISSN 1422-0067
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Physiology
Language en
Keywords polyunsaturated fatty acids; PUFAs; omega-3 fatty acids; α-linolenic acid; ALA; eicosapentaenoic acid; EPA; docosahexaenoic acid; DHA; immune cells; immune response; phagocytosis; immune-modulation; anti-inflammatory; migration; presentation; cytokines; antibody production
Subject categories Immunology in the medical area, Physiology, Microbiology in the medical area


Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although the mechanisms for such regulation are diverse. First, as a constitutive part of the cellular membrane, omega-3 fatty acids can regulate cellular membrane properties, such as membrane fluidity or complex assembly in lipid rafts. In recent years, however, a new role for omega-3 fatty acids and their derivatives as signaling molecules has emerged. In this review, we describe the latest findings describing the effects of omega-3 fatty acids on different cells from the immune system and their possible molecular mechanisms.

Page Manager: Webmaster|Last update: 9/11/2012

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