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Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid

Journal article
Authors V. Johansson
S. Erhardt
G. Engberg
M. Kegel
M. Bhat
L. Schwieler
Kaj Blennow
Henrik Zetterberg
T. D. Cannon
L. Wetterberg
C. M. Hultman
Mikael Landén
Published in European Archives of Psychiatry and Clinical Neuroscience
ISSN 0940-1334
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Language en
Links dx.doi.org/10.1007/s00406-019-01042...
Keywords Biomarker, Cerebrospinal fluid, Chemokine ligand 2, Kynurenic acid, Monocyte chemoattractant protein-1, Twin study
Subject categories Neurosciences, Psychiatry

Abstract

Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. © 2019, The Author(s).

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