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Association of CACNA1C polymorphisms with serum BDNF levels in bipolar disorder.

Journal article
Authors Erik Smedler
Erik Pålsson
Kenji Hashimoto
Mikael Landén
Published in The British journal of psychiatry : the journal of mental science
Pages 1-3
ISSN 1472-1465
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 1-3
Language en
Subject categories Psychiatry


Variation in the CACNA1C gene has been associated with bipolar disorder in several genome-wide association studies. This gene encodes the alpha 1C subunit of L-type voltage-gated calcium channels, which play an essential role in neurons. We analysed 39 biomarkers in either cerebrospinal fluid or serum in relation to six different CACNA1C variants in 282 patients with bipolar disorder and 90 controls. We report associations of CACNA1C risk alleles with serum levels of BDNF as well as tissue plasminogen activator, which converts pro-BDNF to mature BDNF. This sheds light on links between CACNA1C genetic variants and pathophysiological mechanisms in bipolar disorder.Declaration of interestNone.

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