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The Potential Use of Metabolic Cofactors in Treatment of NAFLD

Journal article
Authors A. Mardinoglu
D. Ural
M. Zeybel
H. H. Yuksel
M. Uhlen
Jan Borén
Published in Nutrients
Volume 11
Issue 7
ISSN 2072-6643
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Language en
Keywords NAFLD, metabolic cofactors, l-carnitine, nicotinamide riboside, l-serine, N-acetyl-l-cysteine, fatty liver-disease, l-carnitine supplementation, n-acetylcysteine, oxidative stress, double-blind, glutathione, progression, prevalence, deficiency, impact, Nutrition & Dietetics, simone c, 1994, aids, v8, p655
Subject categories Clinical Medicine


Non-alcoholic fatty liver disease (NAFLD) is caused by the imbalance between lipid deposition and lipid removal from the liver, and its global prevalence continues to increase dramatically. NAFLD encompasses a spectrum of pathological conditions including simple steatosis and non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver cancer. Even though there is a multi-disciplinary effort for development of a treatment strategy for NAFLD, there is not an approved effective medication available. Single or combined metabolic cofactors can be supplemented to boost the metabolic processes altered in NAFLD. Here, we review the dosage and usage of metabolic cofactors including l-carnitine, Nicotinamide riboside (NR), l-serine, and N-acetyl-l-cysteine (NAC) in human clinical studies to improve the altered biological functions associated with different human diseases. We also discuss the potential use of these substances in treatment of NAFLD and other metabolic diseases including neurodegenerative and cardiovascular diseases of which pathogenesis is linked to mitochondrial dysfunction.

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