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Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

Journal article
Authors E. Andersen
A. Altlntaş
Ulrika Andersson Hall
Agneta Holmäng
R. Barrès
Published in Epigenomics
Volume 11
Issue 8
Pages 861-873
ISSN 1750-1911
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 861-873
Language en
Links dx.doi.org/10.2217/epi-2019-0055
Keywords DNA methylation, epigenetic inheritance, gestational diabetes, obesity, pregnancy
Subject categories Neurosciences, Physiology

Abstract

Aim: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors. Methods: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns. Results: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group. Conclusion: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM. © 2019 Romain Barrès.

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