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On-Command Regulation of Kinase Activity using Photonic Stimuli

Journal article
Authors Cassandra L. Fleming
Morten Grötli
J. Andreasson
Published in Chemphotochem
Volume 3
Issue 6
Pages 318-326
ISSN 2367-0932
Publication year 2019
Published at Department of Chemistry and Molecular Biology
Pages 318-326
Language en
Links dx.doi.org/10.1002/cptc.201800253
Keywords chemical biology, kinase inhibition, photocaging, photopharmacology, photoswitching, catalytic subunit, optical control, protein, design, inhibitor, Chemistry
Subject categories Chemical Sciences

Abstract

The underlying role that many kinases play in complex cellular pathways as well as disease remains unclear. To better understand the role that kinases play in both health and disease states, the use of light as an external stimulus to modulate kinase activity with high spatiotemporal resolution has gained increasing interest over the years. Herein we highlight the progress made towards the development of light-responsive kinase enzymes and small molecule inhibitors. In these examples, photolabile caging groups and photoswitchable entities have been utilised to modulate either kinase activation or inhibition in a light-controlled manner.

Page Manager: Webmaster|Last update: 9/11/2012
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