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Cognitive Decline in DM1: a 14-year Longitudinal Study.

Conference contribution
Authors Stefan Winblad
Magnus Rudenholm
Iraj Abedini
Christopher Lindberg
Published in IDMC-12 2019, Göteborg, Konferensprogram
Publication year 2019
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Physiology
Department of Psychology
Language en
Subject categories Clinical Medicine


Introduction: It has been suggested that DM1 is associated with an accelerating cognitive ageing process. The aim of this study was to measure cognitive performance over a decade in adult onset DM1 and to explore disease related and demographic factors. Methods: 25 patients were examined with a comprehensive battery of neuropsychological tests and were rated on muscle function at baseline, five- and fourteen years follow up. Neuropsychological measures were compared to age-normative data on all occasions. Results: Patients performed significantly worse at follow-up. At retesting a significant worsening of attention, executive, visuospatial, arithmetic and verbal ability emerged. Age at onset, disease duration and measures on muscle impairment were not associated with cognitive performance over time. Conclusion: These results shows that aging in adult onset DM1 is associated with accelerating cognitive decline over time.

Page Manager: Webmaster|Last update: 9/11/2012

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