To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Regulation of phagosome f… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Regulation of phagosome functions by post-translational modifications: a new paradigm.

Review article
Authors Paul Dean
Tiaan Heunis
Anetta Härtlova
Matthias Trost
Published in Current opinion in chemical biology
Volume 48
Pages 73-80
ISSN 1879-0402
Publication year 2019
Published at
Pages 73-80
Language en
Keywords Animals, Humans, Phagosomes, chemistry, metabolism, Phosphorylation, Protein Processing, Post-Translational, Proteins, analysis, metabolism, Proteomics, methods, Signal Transduction, Ubiquitination
Subject categories Medical cell biology, Cell biology, Immunology in the medical area


Phagosomes are highly dynamic organelles formed by the uptake of particles through phagocytic innate immune cells such as macrophages. Their key roles in microbe elimination and antigen presentation make them essential for innate and adaptive immunity. However, phagosomes are also important for tissue homeostasis as even in healthy individuals billions of dead cells are phagocytosed each day. In this short review, we highlight how the use of latex beads as inert baits for phagocytosis and subsequent analysis by proteomics has changed our understanding of the phagosome. We further discuss recent data on post-translational modifications such as phosphorylation and ubiquitylation that regulate phagosome functions and demonstrate that the phagosome is not only a 'degradative organelle' but also serves as a subcellular signalling platform.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?