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Silybin Against Liver Ischemia-Reperfusion Injury: Something Old, Something New...

Journal article
Authors Mihai Oltean
Published in Journal of Investigative Surgery
Volume 31
Issue 6
Pages 521-522
ISSN 0894-1939
Publication year 2018
Published at Institute of Clinical Sciences, Department of Surgery
Pages 521-522
Language en
Keywords liver, ischemia reperfusion, flavonoids, protection, Surgery
Subject categories Surgery


Ischemia reperfusion injury (IRI) is a life threatening condition that may develop after elective liver surgery or liver transplantation. Numerous surgical and pharmacological approaches have shown varying degrees of protection against liver IRI. A group of protective compounds are the flavonoids but their intestinal absorbtion and bioavailability are low and impredictible. In this issue Tsaroucha et al. reports significantly decreased hepatocellular injury, Fas/FasL expression and inhibited HMGB1 release in rats receiving a hydrosoluble, lyophilized complex of SLB and hydroxypropyl-beta-cyclodextrin (SLB-HP-beta-CD) intravenously.

Page Manager: Webmaster|Last update: 9/11/2012

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