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A Three-Color Fluorescent Supramolecular Nanoassembly of Phototherapeutics Activable by Two-Photon Excitation with Near-Infrared Light.

Journal article
Authors Aurore Fraix
Vladimir Kirejev
Milo Malanga
Éva Fenyvesi
Szabolcs Béni
Marica B Ericson
Salvatore Sortino
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
Volume 25
Issue 29
Pages 7091-7095
ISSN 1521-3765
Publication year 2019
Published at Department of Chemistry and Molecular Biology
Pages 7091-7095
Language en
Links dx.doi.org/10.1002/chem.201900917
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Nano Technology, Biophysics, Materials Chemistry, Biophysical chemistry

Abstract

A supramolecular nanoassembly, of about 30 nm in diameter, that consists of a green-fluorescent, β-cyclodextrin-based, branched polymer co-encapsulating a red-emitting singlet oxygen (1 O2 ) photosensitizer and a nitric oxide (NO) photoreleaser, which comprises a blue fluorescent reporter, is here reported. The system exhibits "five-in-one" photofunctionalities. All components can be simultaneously excited in the phototherapeutic window with two-photons by using near-infrared light at 740 nm and despite their close proximity, behave as independent units. This allows for their in vitro visualization in carcinoma cancer cells, due to their distinct green, red, and blue fluorescence, and for the production of both cytotoxic 1 O2 and biofunctional NO.

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