To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Nine Amino Acids Are Asso… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men

Journal article
Authors J. Vangipurapu
A. Stancakova
Ulf Smith
J. Kuusisto
M. Laakso
Published in Diabetes
Volume 68
Issue 6
Pages 1353-1358
ISSN 0012-1797
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1353-1358
Language en
Keywords branched-chain, resistance, hyperglycemia, metabolomics, sensitivity, predictors, metabolism, tolerance, glycemia
Subject categories Endocrinology and Diabetes


Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have investigated the association of AAs with insulin secretion in a longitudinal setting. Our study included 5,181 participants of the cross-sectional METabolic Syndrome In Men (METSIM) study having metabolomics data on 20 AAs. A total of 4,851 had a 7.4-year follow-up visit. Nine AAs (phenylalanine, tryptophan, tyrosine, alanine, isoleucine, leucine, valine, aspartate, and glutamate) were significantly (P < 5.8 x 10(-5)) associated with decreases in insulin secretion (disposition index) and the elevation of fasting or 2-h glucose levels. Five of these AAs (tyrosine, alanine, isoleucine, aspartate, and glutamate) were also found to be significantly associated with an increased risk of incident type 2 diabetes after adjustment for confounding factors. Our study is the first population-based large cohort to report that AAs are associated not only with insulin resistance but also with decreased insulin secretion.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?